Hamilton is located on the banks of the Brisbane River, approximately 7km north of the Brisbane CBD. The suburb is dominated by Hamilton Hill, from which residents enjoy spectacular views of the river and the city. Views also extend to Mount Coot-tha to the west and Moreton Bay to the east.

Throughout Brisbane's history, Hamilton has always been the city's most prestigious suburb, and is generally referred to as one of Brisbane's "old money" areas. In the early days of Brisbane, Hamilton was home to many aristocrats and clergy, and today is still home to many of Brisbane's most powerful families, as well as the city's business elite.